I like that, because I like Zenos as a character. My moral disgust with his actions doesn't mean I can't admire his fiercely individualist philosophy, and the big lesson he has to learn in Endwalker (that you have to care about what other people want instead of selfishly pursuing your own interests to get anywhere) elevates him from villain to nominal anti-hero by the end.
While it's true that Venat blasted humanity back to the Stone Age (so to speak), she never shaped their beliefs in any way, shape, or form that's been shown. Other than people referring to the planet as Hydaelyn (instead of its Ancient-given name Etheirys, with the reason behind this unclear) and indirectly intervening whenever the Ascians step up their game, she is shown to have an extremely hands-off approach to the advancement of civilization or direction of religion. It's unclear how or why the Eorzeans came to worship the Twelve, but other than that no religion is shown to have any relation to Hydaelyn whatsoever.
It's not that I find Venat's actions cool (or not monstrous), but they're a (fictional) historical thing that happened, and arguing about whether it was cool or monstrous strikes me as wasteful. What's important is whether or not her plan worked (it did), whether or not anyone had another plan to actually deal with the root cause or even wanted to do so (they didn't), and where we can go from here (anywhere we want, as opposed to the Ancients' / Ascians' plan leaving everyone bound to the Amaurotine ideals that indirectly caused the mess to begin with).
Nihilism is just a philosophical stepping stone towards anti-nihilism ("nothing has any meaning" -> "nothing has any meaning so I will impose my own meaning on it").
That said I acknowledge the story concludes that people live for others' sake (see Zenos learning this lesson, above) but would argue that's largely a consequence of the Eastern collectivist mindset bleeding through in spite of the Western existentialist philosophy it leans so heavily on. An indidivual's "answer" doesn't necessarily have to be individualistic, but it has to be something you reach on your own in order to live a truly fulfilling life.