Basically, if you can survive tank busters then you are good to go. You don't need any more health than that, any more is usually detrimental in fact (puts more strain on healers, doesn't benefit you in any way). All points in str is also the way to go, as you generate more enmity and deal more damage that way (again, the extra health is useless). The "optimal" setup is full pentamelds, but that can be expensive and lower your ilvl (which generally isn't an issue, but can be in some cases).

I use 3 slaying and 2 fending right now, but that's because I'm still in i170 left side gear and don't want to spend the money on pentamelds.