I think the issue is that in order for transgenderism to "work," it requires having everyone adhere to the system set by those people.
If one person defies the system, then the people who set it, get really defensive. The reason for that is due to how it's currently structured and where it's coming from.
The biggest issue with the structure of their system is that simply questioning any aspect of it, gives them grounds to immediately dismiss everything you say henceforth under the grounds of being a "transphobe" or something else, simply because you questioned it. Usually, if something is strong or comes from a good foundation of existence, you wouldn't need to get defensive at the mere questioning of it, since you would've had confidence in who you are to begin with. You wouldn't need to argue with people about who you were, if you believe in yourself. You may not harbor any hate whatsoever to them, but they will convince you that you are hateful, regardless of the situation or any deeper context around it.
Where it comes from, is the people centered around them convincing them something is true. There's a phenomenon called the "illusory truth effect" where repeated exposure to any false information can cause someone to believe that information to be more true then actual true information. If you for example are repeatedly told left handed people are full of sin. You might end up believing that, because you will compare it to something you already know to be true, then because something is more familiar due to repetition, that familiarity can overpower the truth. Causing someone to believe something just from repeated exposure to it. Familiarity overpowers rationality.
All this tells me is that the social aspects of transgenderism don't really have a sturdy foundation to them, because when you question anything, that social illusion is broken, causing defensive behavior. You have to play House essentially or else face ostracization, if you happen to be speaking in an area that houses alot of people who play it willingly.
More on topic with the game, I want to see the next Live Letter and see how the team responds to the feedback of the MSQ. They may just flat out ignore anything to do with Wuk to keep discussion down. But it will be interesting to see if any of them respond to the MSQ at all