The Definition of "Handsome"

[Gemina]

"Yes, you can use the adjective handsome for women.

While handsome is more often used for men, women can also be called handsome. When a woman is described as handsome, it suggests that she is very good-looking, and also healthy and strong. Handsome is less likely to be used to describe a woman who is petite or delicate.

...or feminine.

From my experience, when a women is called handsome it is not used as a term of endearment. It is used offensively.