Possibly the closest we've had to "complex application of DoTs" is BRD before they started increasing the duration of Caustic/Stormbite up to 45s. While reapplying wasn't complex, but you wanted to work backwards to time your DoTs so ideally you'd be refreshing Iron Jaws in that 2-0s window so you get the extra tick while also landing it on some sort of beneficial buff - whether it be a self-buff (RS) or a group buff (like chain). Or you'd have to do a fight long enough to figure out that since the boss jumps at a certain time, it might make sense to let IJ drop entirely since you wouldn't get enough ticks.

When there were less ticks per DoT, getting that last tick became more important. However, they dropped the potency of Caustic/Stormbite back in ShB (if I recall?). So while it is nice to get that last tick, the DPS loss is smaller. Of course, you'd rather land IJ a tick early than have to spend 1 extra GCD reapply both DoTs individually.