In Mass Effect, I prefer Fem Shep because I prefer Hale's voice work over Meer's. Probably doesn't help that my first run with Man Shep was also an attempt at a Renegade run, and ME1 Renegade is just......thoroughly unpleasant. Sounded less like a badass antihero and more like a pissy kid playing internet tough guy.

Plus, Man Shep can't romance Garrus. Best option, IMO.