Hythlodaeus being the 'Speaker of Nonsense' could also be a playful reference to his personality. He has an established friendship with Emet-Selch and Azem, teasing both in the manner a close friend is prone to get away with.

It also wouldn't be the first time that a reference was 'reversed'. Doma's river, in FFVI, is poisoned by Kefka. Doma's river, in FFXIV, is exploited as a means to flood Doma Castle in order to more readily attack Yotsuyu and her forces.