Can we get choices that really matter and have a effect?

[SturmChurro]

No, if you shoot Mordin or Wrex in Mass Effect 3, their replacements will not appear in the game. Their characters and their respective roles are dead by the point.

What exactly are you debating? Mass Effect 3 is a continuation of Mass Effect 1/2. Wrex can be killed in one and Mordin in 2. When either of these occur, wrex gets replaced by a character who fulfills the exact same literal role in the story, and in mass effect 3 wrex's replacement appears again, that fulfills wrex's role again to the exact detail. You can literally end mordin's replacement just like you can end mordin. The end state you are stating is changed in name of that character only, the results are all the same, meaning the choices ultimately do not matter in the overarching story. In any of the games. As stated earlier, "illusion of choice". If you keep Mordin and Wrex alive to fulfill their roles in 3 the only differences are voice lines, not the story. Now, if we are talking about 'The Citadel' DLC, wrex and other classic character appearances can change the feeling of it there, since that whole DLC is just fan service.