If you're clicking abilities with a KB/Mouse setup, most will say you're doing it wrong. I won't since that's player choice. However when you use a KB/Mouse, the mouse is for movement and targeting, not clicking skills, if you want to use it to it's full potential that is. Thumb buttons on the mouse make it even better, ie things like the Naga (I despise Razer products, but it does what it advertises) This gets debated time and time again, and people bring preference into the picture. Comparing one input method to another without the human variable, KB/Mouse will outshine a gamepad in a game of this design unless severely handicapped on purpose.