I'm getting eye strain too, and I had an eye exam come back clean a few months ago. (Technically I'm slightly photosensitive, but at the "my body will remind me to wear sunglasses" level rather than anything remotely limiting day-to-day.)
For me, the culprits seem to be:
- Forced upscaling. The blur causes my brain to attempt to refocus my eyes by reflex, and of course fail because my eyes are already correctly focused on the screen. Lots of wasted eye muscle work. This is especially true because my character model often gets blurred while moving, and that's exactly when I usually need to look at my feet / the arena floor. Seeing a blur right in my central vision really invokes that refocusing reflex.
- Forced bloom. The aggressiveness of the bloom trips my photosensitivity, despite my monitor already being set at minimum brightness and playing in a well-lit room. This is particularly so when the heavy glows are close to low light, either in space (e.g. the Allagan / Garlean magitek aesthetic) or in time (e.g. cutscenes with explosions). Plus, the bloom obscuring whatever's around the light source often gets processed as blurry to me - and invokes the same refocusing reflex - because I'm a disabled raider and I need to process visual cues fast in order to respond on time.
- Relative saturation between new and old textures. Some of the new textures, such as those for housing yards, are quite grey compared to older ones... including my armor and my HUD. I've tried adjusting the gamma, but every possible setting either undersaturates those new textures (making them process as blurry, or at best a dying lawn) or oversaturates my HUD.
I've already turned Radial Blur off, and I've tried Anti-Aliasing on both FXAA and off entirely.
Hopefully we can turn off upscaling soon, in addition to regaining the option to turn off bloom. That and a texture saturation pass would fix my personal eye strain issues.