I rather hope that SE makes some fixes to UI customization and then puts software to detect 3rd party software on our machines. I really do. Yes SE will take a hit in subscribers for awhile. Yes the outrage will be enormous. Doing this will accomplish a few things.

It will instantly neutralize reporting/ban trains. SE will be able to say we use our own internal data not these reports.

It will finally put an end to any number of bots that are plaguing the game from PvP to Crafting to MB to gathering. These I personally feel are a whole lot bigger of a problem than what is being gone after now.

It will be a completely even playing field. Everyone will know if you use 3rd party software you are toast.

Will SE do this? Probably not. I really do wish they would.