Maybe they could use the DNC system in a way that will help HQ a difficult item via a buff for successfully sequencing based on need.

Example: Goldsmith Earring of Zodiark, requires 330,933 quality. If you sequence properly, you gain a super buff to quality on your next Touch ability within the next X turns. Or you can sequence so you gain a buff to your next Synthesis on items with steep Craftsmanship requirements. Etc.

Little quirks unique to individual items/item types that require mini-games on the initial successful craft. After you beat the challenge, you can macro as normal.