If your primary symptoms are muscle fatigue in the hands and wrists then maybe something a little more deliberate in rotation would be better.

From what I've heard from my mage buddies ( i'm not really a ranged DPS style player ) they are a little bit more deliberate in their rotations. Involve a little less twitch reactions and more thinking ahead and knowing a fight. This might feel a bit more comfortable for you once you have a good grasp on a fight or instance as you wont have to keep circling a mob to hit positionals like on a melee DPS. If outputting maximum amount of DPS and keeping up positionals is important, then your gonna be moving both hands quite a bit to keep up with the melee DPS style gameplay in this game. Even if the rotations are a bit simpler.

Just some thoughts for you to consider.