I never had any of those 'suddenly amazing while drunk' player and only the 'im going to black-out just enough so the party will wipe yet again and then laugh about it' type of person, so to me now if I get anyone drunk or high in duty I'm more likely to leave at any sign of things going bad, tired of having to deal with people doing what they want and expecting to get people who enjoy wiping 5 times on the same thing.