To clarify, you have to be out of the Red-Zone before it disappears, not before the attack goes off. If you don't make it out of the Red-Zone with around a second to spare, you might as well just stop moving and take your death like a man. Most people seem to think that the Red-Zones are just indicators of where the attack is going to land when the enemy fires it off. It's actually a visual timer. You have to get clear of it before it disappears.

You need a good reaction speed to play this game. It can be very punishing if you don't.