Just for reference my setup:
Core i7-3770K
Sabertooth Z77
32GB RAM 1600MHz
GTX680 with 326.80 drivers
Windows 7 64bit

I haven't had any issues like the ones you describe myself...

Have you tried to disable your internal audio device, just to see if the lockups/crashes stop?
Or just changed audio settings in Windows to be stereo only or something...

I can't tell if it's an SE issue or something with your computers, but doesn't hurt trying various stuff...