With the speed of clicking:

I use a Logitech G500 mouse, so I can have it set to where the arrow flies across my speed with me not even moving the mouse much.

Now onto the targeting stuff:

With the tab-targeting and controllers, I have a lot less accuracy with targeting, personally. (Takes forever, if I hit it one time too many, I have to go through the entire list (or maybe more!) again, hoping I get it right that time, etc.) So I personally do MUCH better with a keyboard+mouse setup, and I spent most of my gaming life using consoles!

And yes, I have used a gamepad. Well, a PS2 controller, anyway. Targeting wasn't as accurate (for me, personally..) as my mouse was in this game. (I use it for XI, though.)