We've been gifted a macguffin that should allow for easier cross shard travel, but we don't know how to use it yet. And there are still parts of Etheirys we have yet to see. The implications that the key has ties to Azem is another mystery as well. I also feel like we've only just started scratching the surface of 'soul stuff.' Alexandria brought with them Electrope technology which is going to impact the world. There are probably a some other things that I'm not considering as well. A lot of doors are open.