Don't use ability macros. Please don't. I am begging you, pleading, on my hands and knees here, do NOT use ability macros! Whatever semblance of amusement or cleverness they may have (which usually isn't much to begin with) wears off with each subsequent press of that ability.

A custom hello/goodbye message macro is fine. But if you want to say something funny during a duty, you can't just hit the "funny macro" button, you wait for something to happen that you can comment on that people can laugh at, because good comedy requires context and timing. I've seen some great comments in chat during roulettes that genuinely made me laugh and made my night, but I can guarantee you they were never once a macro, they were comments someone typed on the fly that only made sense and were funny in that specific context.