I wonder as well.

With the trust system, are they just going to block out Ryne for MSQ dungeons now that we're back on the source and a new dungeon just so happens to take place there? Would be a little jarring so I think she'll end up being very curious and pop in to see us next patch with Gaia in tow (after the events of the last raid tier naturally.) Maybe they use Eden as a means to traverse worlds? Wouldn't surprise me one bit.

Honestly, now that she has that gunblade, I'd like to see a "Future Ryne" basically pop up and warn us about "impending doom" before the events of 6.0