Would it be possible to play the game off a USB Flash Drive?

[Soukyuu]

flash drive life would ware out pertty fast from this game, unless your using a SSD

Again,

The only time the flash drive is getting worn out is when you write something onto it - reading does not wear it out, just like SSDs.

The only difference between a flash drive and a SSD is the speed and size of flash memory chips. Flash memory is flash memory.