So you do what it to be like a raid boss. Do macros bother you that much? It wouldn't make crafting more "interesting" or exciting- it would simply make it more tedious and expensive each time you responded incorrectly before a timer ran out. Unless you had a single second to respond to each new "crisis", it still wouldn't be complicated. It would only be to ban macros (which you insisted wasn't your goal, but obviously is).
Hell, if you want fun and complicated, add algebra into the equation. Make us do quick math in our heads. Yes, before you ask, I actually WOULD enjoy that.