Seems like Yotsuyu doesn't even recognize her own reflection which is what I assume the scene at the beginning of the trailer is (I'm assuming that's a mirror) and probably a bit of the conflict in Doma will be what they do with her as a result of that. Though it's a bit of a cliche it does present a certain conflict. In real world crimes committed by mental ill people are treated differently because of the awareness of the consequences of actions can be a bit shaking and certain treatment can fall under cruel and unusual punishment.

Though not like our world, Hien's personality and ethics could provide some hesitation to the matter of killing or imprisoning someone who doesn't even remember what they did, regardless of how sadistic or horrible the original act was. I'm kind of interested to see where that goes exactly. Regardless of the involved cliche.