First things first:

Playstation controllers of any kind are not supported by Windows.

Are you using ds4windows for your controllers? If not, then you will need to install this and calibrate your PS4 controller within this software. It basically fools windows into thinking your PS is actually an X360 controller, and this, in iteslf, isn't perfect and does have it's share of problems. For this reason, anybody who is looking at this and considering using a controller, make your life easy and use an officially supported controller such as an XBOX 360 gamepad.

Are you using the PS pads wirelessly via bluetooth? If so, then you may be getting some outside interference that is causing this issue. You also may need to update the drivers for the bluetooth device itself. Also, calibration would take place within the ds4windows, not the ingame calibration tool.