I'm not sure what to answer.

Yeah, ruin 2 is pretty bad but it's still an instant casted spell, if you're moving away from a target it's the only weave option available. Though I'm not sure about the sanity of those who actually do this. It can get somehow a little worth you use energy drain on something else on it. And it doesn't cost a lot of mana
Miasma 2 on the other hand is good. It 100 potency on hit et 100 potency over 12 sec, there's no reason to use it when you want to cast an instant and bio 2 is already up. I'm not sure why you would want to consider weaving with addlo but not that.

And ET is now 20 sec CD. And it's basically one of the few thing you can fire if your co-heal can't save life. Not sure why you wouldn't use that on prog'. It seems you're talking without taking 4.06 changes into consideration.