I don't take Largesse for SCH or AST and take E4E instead. My viewpoint on Largesse is that there's nothing in the game that requires that additional healing if I'm geared, and I just don't go into fights I'm not geared for. It alleviates some MP usage in certain situations, but there's only so much HP I can restore before I hit that player's cap.

For SCH, E4E synergies with DT still which makes that particular skill more useful along with adlo shields.
For AST, I already have a 10-15% buff to my healing output that just exists on me at all times thanks to my sects. Do I really need to push it another 20% if I'm doing my job properly?