That single-target bomb during Ozma that insta-kills you if you move or attack is the only thing that still really gets me, but only because I'm usually busy concentrating on other mechanics during that fight.

Besides that, trying to find the darn hole in the web during the first boss fight is annoying. I don't know if I'm just blind or something, but I'm always running around trying to find it (then, when I finally get down there I'm targeted and pulled back up, lol). :P