Also if you open up the world map in-game, and then zoom in to the regional map in-game, nothing really adds up either. On the map there is a huge gap between Eastern Thanalan and South Shroud, but in-game we can clearly see where the two zones meet. Additionally, South Shroud literally sits just a bit east of Mor Dhona, but there has (afaik) never been any path from south shroud to Mor Dhona. There was I believe an old 2.0 beta map that had a connection where Lost City now sits, which would explain that space at least somewhat. Correct me if I'm wrong, but the area could be Amdapori(sp?) ruins and are blocked by the elementals.
Also, according to the game map, there is a vast section of unexplored land south of Ul'dah and South Thanalan, as well as further to the East of Eastern Thanalan, a large chuck of area that on the Thanalan map is in Mor Dhona, but isn't part of the Mor Dhona map at all, O'Ghomoro as mentioned above, and lets not get started on Coerthas...
bottom line really is there are some glaring inconsistencies with the in-game maps but there is also room for expansion and exploration.