Two things about DOTS.
1) DOTS in this game snapshot, therefore if you have berserk and unchained up when you apply the DOT even if the buffs fall off, the dot will still tick for the increased potency.
2) DOTS can crit (for those of you who don't believe this take a look at bards. One of their cooldowns is based off of dot crits).
Based on these two bits of information its always better (if you can manage it) to apply fracture when your cooldowns are up. Also Internal Release + Wrath Stacks can increase the probability that you will get a crit but they don't increase the damage directly.



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