It's inconsequential to enjoying the game for you. It is not for me. People assuming I'm a guy is something I already have to worry about in the real world, I don't need it in the video game as well, and every time I get called 'he' despite all my attempts to present as female without drawing attention to myself, it's a reminder of all the fear and bullshit I have to deal with in the real world. I dunno about you, but being constantly reminded of shitty real world stuff does not make for an enjoyable gaming experience for me.