I've never really had this problem as most of the lasers seem to be in synch. Also, I noticed that some of the lasers appear to have blind spots. That's to say, I will notice a line in front of the laser, but a snub of a line behind the laser. I'd have to look at this more, but all I can say is that your DD need to burn a few of them down fast to give you more room to work with, especially for the AOE blasts. I've never had an Ultima group that didn't down it. I got Ultima on my first go in a DF pug. Not really sure why some people appear to have really bad luck with this run.