The Monk Temple

[Almalexia]

As far as I've been able to discover*, DoTs are affected by the active buffs you have at the time the DoT is executed. Meaning that activating the Twin Snakes buff before applying Demolish on an enemy will take the 10% damage bonus into account for each tick. So, instead of the usual 40 potency per tick, it'd be 44. Which adds up to a total of 264 rather than 240.

Just ran outside and tested for myself. By god, it's true!

DoTs are not only affected by +X% multipliers, but STR and crit as well. There is no reason to not have DoTs active as long as your target can soak most of it.

I want to point out "potency" is a part of a larger calculation. Bonus damage from Twin Snakes (+10%), for example, doesn't turn 40 potency into 44 potency; it adds 10% more damage to the formula after all other factors are considered. In other words, you are underestimating how much +X% damage affects your output.