I'm guessing you use WASD to move? If so try to make use of Q E R F etc as well. Basically putting rapid fire things on hotkeys around your movement cluster. MOBA style binds effectively. As Semi mentions, getting binds onto additional mouse buttons is also a good time.

One other big point is how you target people. I actually primarily still use 1 through = with Control and Alt modifiers, with 2 extra mouse hotkeys for specifics such as ground targeted stuff like Asylum/Lily/Soil/Star. However where I make up time over many is through being very rapid at targeting party members with F1 through F8. If you click to select, that's an area where you may likely have even more room for improvement, either through practicing mouse movements with something like Osu or trying to adapt to using F keys to target party members instead.