I really would like if the prophecy from the Golden Dhyata comes true and that something about the Lifestream begins to inexplicably change and cause the chaos the world over.

The talk of it "birthing new flesh" has particularly...interesting implications if taken literally, given suggestions that life can appear naturally and that the Ancients were one of such forms of life, which could eventually tie back into existing mysteries about the nature of the Echo, where souls come from, etc.