I can't believe we finally have a certain someone's biggest fan right here in our very own guild!
You know... Since they've had to spell out so many things in the Q&A session, I really wish Ishikawa would come out and clarify whether she absolutely 100% intended to write Hermes as mentally ill or not. Because while I subscribe to the headcanon myself (and then he is cared for, listened to, treated, finally opens up to people around him who, by the way, are fully human with a complete range of emotions including grief and he makes friends with the Convocation and him actually earnestly defending mankind against the Final Days finally makes some sense AND IT IS WHOLESOME OKAY), as far as I know right now it remains just that: headcanon.
Meanwhile, the sidequests are sidequests, and quite frankly, in the MSQ itself as well as Yoshida and Ishikawa interviews, I don't see many indications that we are not supposed to take Hermes at face value as a rational man of his time and culture, and his line about testing mankind just like they test creations as an OHHHHHHHH SICK BURRRNNNN (TIP: An entire established and complex civilisation is not comparable to constructs that were just made and unmade). I get it, I truly do – as an Ancient, Ascian and general villain enjoyer, I, too, want to twist Fandaniel's bizarrely written multiple characters past and present into a coherent, satisfying whole – but in the absence of evidence, I am going to consider Depressed Hermes as something of an excuse for the mess of a storyline we ended up getting, and a prop for Endwalker enjoyers to wield against the very bad, terrible, no-good detractors. In case of emergency, if "you clearly didn't pay attention to the plot" didn't work, press the "as someone who has been diagnosed with depression, Hermes was extremely relatable, not that you would know of course" button. (I do. He still isn't, to me.)
I believe this is what happens when you shove Endwalker into a mixer, add some Kool Aid and drink the resulting smoothie.
aS aN hEaLtHcArE wOrKeR, I wouldn't particularly recommend it, however. I would rather have Charmion's smoothies.
(Edit) btw, you guys hyped for having your expectations subverted in 6.2 and finding out Lahabrea isn't Hephaestus? And having Erich turn out to be actually Our Lahabrea? It's always tickled my funny bone that by far the most convincing argument for the "Erich really is Laha" theory, which I first bore witness to at the prestigious Reddit Academy of Clownship, is "Yeah, it doesn't make any sense considering the Tales From The Shadows backstory, but I mean have you seen the rest of Endwalker?". Truly a point to consider.