Leaving aside the fact that there are many workarounds for the slightly-odd targeting priorities this game has (I've got cycling the aggro list bound to my mouse wheel, as an example, then have "target nearest" set to a hotkey sequence bound to one of my keyboard's gaming macro keys, thus allowing it to be near my hand's resting place)...

Quote Originally Posted by KurohNeko View Post
Just make it so your tab button locks on nearest enemy and done. Want to get fancy? Whatever the tank is targeting.
...I'd argue this method falls a little short if you are the tank.