I don't have any disability beyond hand pain (which I mitigate with a controller), but I have a friend that is color blind. He couldn't do E7S without either ACT or a raid member calling out portals because he actually couldn't see the difference between the two portals even with color blind mode on. He had similar readability issues with E6S, P3S and likely would have the same issue with P4S having blue/purple tethers. The accessibility options should be so good in this game that people don't have to rely on a third party program to make it playable.