I'm hoping for at least one or two major deaths where the Scions/City State leaders are concerned. The premise of Endwalker is supposed to be the second coming of the apocalypse so it'd be strange if nobody of note ends up dying.

G'raha, Urianger, Y'shtola, Alphinaud or Alisae would be my picks. Other then those five, I'd like Zenos to go away permanently.