My speculation:

- The Thavnairian and Garlean Consulates within Kugane will finally be accessible and put to use.
- We'll be using Radz-at-Han as a way to gain access to Ilsabard. Though we'll have to deal with some local problems first once we get to the city itself.
- There will be more than one new zone located within Ilsabard.
- 'Garlemald Reconstruction' will play a part throughout the expansion. We won't necessarily fix the capital itself, though. Instead we'll help the displaced Garleans create a new home for themselves somewhere warmer and more hospitable.
- Garlean magitek will be key in turning the tide of battle when confronting Zenos and Fandaniel.
- Things will end badly for both Hydaelyn and Zodiark. They will both be revealed as victims of a much larger threat in the form of whatever being caused the destruction of the original Star.
- The Warrior of Darkness will become the Warrior of Balance.
- The MSQ's will be longer than usual for a base expansion.
- We'll be exploring the interior of the Moon rather than just the surface.