I'm relatively new player, but not exactly newbie (I play since last year's november). There is still so much things that I do not unlocked yet. Like, yesterday I just started Hildebrandt questline. Not so long time ago I totaly randomly unlocked this turtle quest in Ruby Sea that unlock you some dungeon and trials. I didn't touch proffesions until I finished MSQ. I still do not beat Palace of the Dead. It's not World of Warcraft where you need to do every daily system in game to be viable. You just do what you want. Only MSQ and quests that unlock for you main features of game are necessary.