SE ban bots and RMTs in waves every few months.
Unfortunately this means for those few months the botters and RMTs have free reign and are only moderately disadvantaged for a short time when those ban waves occur.
The most affected part of the market however is the sale of crystals/shards/clusters, which would likely be prohibitively expensive if it wasn't for those botters to be frank, so it's a double-edged sword.
If SE could be more proactive on the issue, they would also need to address the balance of obtaining crystals and shards in great enough quantities as well.