Dump all the extra clicks.
There's no need for a confirmation click on a transport (door, Amaro, elevator) if you can easily turn around and return.
NPC dialogs: If you've seen it once, that's enough. Stop making me clear the same ones over and over again.
Retainer interaction. You should be able to end it by just walking away, no matter what level you're in.

Crafting: Let us switch crafts at any time, without having to close the interface, reopen it, and then find the thing you were just looking at in the recipe.