Until a couple of months ago, I had no idea that clicking most of your skills isnt the "usual" way to play the game.

I move my character with WASD (obviously) can comfortably hit 1-4, with 5 being a bit of stretch on my keyboard. So... any skill that isnt on 1-5 gets clicked and its working quite well for me. I dont think I could get used to a mouse with an extreme amount of buttons (and I like my current mouse very much)...