Essentially, don't use Defiance whenever possible.
It offers no defensive value to yourself and only serves for enmity and tank busters. Even with Mist tank busters (savage Alex included) you don't need Inner Beast nor higher max HP for it. Using Vengeance or Holmgang is usually more than enough. Holmgang is a ridiculously low cooldown timer for what it does. Use it in place of other cooldown whenever you see fit. Never hold it for a 'possible emergency' since ideally, emergencies do not happen.
The entire Warrior gimmick is pushing out high DPS, this includes while main tanking. So an Unchained pull of you must but the rest of the fight should be completely comfortable in Deliverance.