There seems to be three major things mentioned here;

1) What Yoshi-P said about Zenos being a completely unsympathetic character seems to contradict what was said at Fanfest, that we'd see a much more nuanced side to Garlean occupation once we see it for ourselves, instead of through the biased filter of the Resistance. Personally I hope it's going to be both and also directly tied to the fallout of that vicious civil war Garlemald just had.

2) Estinien is going to remain a main character. My main tank has a theory that he's just going to continue cosplaying Kain Highwind and will be entering the "Hooded Man" phase next.

3) Regarding the teaser trailer, Yoshi-P said "Players who have been following the scenario from 1.0 will notice that something is 'off'". My favourite theory on this one comes from Reddit, which is that because the Derplander seems to have aged again we're about to see another time-skip (Gracious Althyk, grant us your blessing, save us from this time bubble).