Everyone's advice has been spot on so far.
My Favorites of the advice:
1) Add Materia to Armor/Weapons you sell (V Control would be the most logical IMO)
2) Sell intermediate items like HQ High Mythrite Ingots, Leathers, cloths, etc
3) PF Advertise your crafting (I usually charge ~200-500k for HQ end synths) for items which normally go for 3-5 million.
During patch updates commissions can be around 1m, while during patch drop offs 100k can be reasonable as well.
4) Sell other items outside the most popular items, furniture, glues, foods, potions, things which are both picked up infrequently (and selling competition is low with large profit margins) and items consumed frequently with small profit margins.
Also make sure to spread your sales out among multiple options. So when one thing goes ill, you can simply drop price till you're out of the market.