At level 40, or any of the levels before you get redraw, it is best to spread a card before you royal road it. That way you do not AoE a Bole when you just wanted to give it to the tank. Like, when you draw a card, and can not use it right away, but might later, spread it. Then you can draw and use the next card. Once you get redraw all of the advice above is golden. At lower levels, best to chose the effect card with spread before using the RR effect so you can give out "singles" while you wait for that effect card.

Just was not sure if wanted advice for using spread at your level or when you get to 60.