With drivers 275.33 I'm running full screen 1920x1080 (v-sync needs to be forced on), 4x aa, 8, 3, Shadows Lowest, Texture Q High, Texture F Highest, and in game shadows and dust turned off. Only issue I encounter is when changing wards it'll skip a second or two if i start moving to soon after zoning, other then that it's flawless everywhere else.