the general DF consensus on Chaos Datacenter is usually "activate Dread before Mines before anything else"
If you put the A and B markers on the towers, and explain where and when to go, it's usually pretty good (people wipe on ballistic no matter how much you explained though >< )
not totally wrong, but not totally right either.
Each time two towers gain a level together, the boss will get a damage buff. That's why you "activate" them to give them some stacks in advance. That way the boss won't get buff. You don't need to stay in the tower after activating it (each activation gives a debuff on the people in it so it's easy to know how many stacks there are ^^)
If two towers fully charge at the same time (either ignored or receiving the same amount of stacks), you'll get a special reward : atomic ray ( 30k raid wipe

)