certainly harder to play to full potential, but not a huge deal for such a basic game


awkward casting and moving simultaneously,
can't use parsers,
some classes you're gonna want more than 16 skills available so switching bars can be clunky,
you're gonna want a smartphone or laptop next to you for teamspeak/mumble or similar,
placing your pets/shadowflare/sacredsoil etc. involves changing camera angles and stuff instead of clicking on the floor,
and obviously its gonna take ages if you actually need to type something.